Current theoretical models fail to predict the topological complexity of the human genome

Current theoretical models fail to predict the topological complexity of the human genome

Understanding the folding of the human genome is a key challenge of modern structural biology. The emergence of chromatin conformation capture assays ({it e.g.} Hi-C) has revolutionized chromosome biology and provided new insights into the three dimensional structure of the genome. The experimental...

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Bibliographic Details
Main Authors: Javier eArsuaga, Reyka G Jayasinghe, Robert G. Scharein, Mark R Segal, Robert eStolz, Mariel eVazquez
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
chromosome organization
Hic
DNA knotting
Lattice models
equilibrium globule
BFACF
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmolb.2015.00048/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmolb.2015.00048/full

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