Translational Relevance of Advanced Age and Atherosclerosis in Preclinical Trials of Biotherapies for Peripheral Artery Disease

Translational Relevance of Advanced Age and Atherosclerosis in Preclinical Trials of Biotherapies for Peripheral Artery Disease

Approximately 6% of adults worldwide suffer from peripheral artery disease (PAD), primarily caused by atherosclerosis of lower limb arteries. Despite optimal medical care and revascularization, many PAD patients remain symptomatic and progress to critical limb ischemia (CLI) and risk major amputatio...

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Bibliographic Details
Main Author: Keith A. Webster
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Genes
Subjects:
gene therapy
cell therapy
peripheral artery disease
critical limb ischemia
preclinical models
clinical trials
Online Access:https://www.mdpi.com/2073-4425/15/1/135

Internet

https://www.mdpi.com/2073-4425/15/1/135

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