Therapeutic Targeting of Endosome and Mitochondrial Reactive Oxygen Species Protects Mice From Influenza Virus Morbidity

Therapeutic Targeting of Endosome and Mitochondrial Reactive Oxygen Species Protects Mice From Influenza Virus Morbidity

There is an urgent need to develop effective therapeutic strategies including immunomodulators to combat influenza A virus (IAV) infection. Influenza A viruses increase ROS production, which suppress anti-viral responses and contribute to pathological inflammation and morbidity. Two major cellular s...

Full description

Bibliographic Details
Main Authors: Eunice E. To, Jonathan R. Erlich, Felicia Liong, Stella Liong, Raymond Luong, Osezua Oseghale, Mark A. Miles, Paris C. Papagianis, Kylie M. Quinn, Steven Bozinovski, Ross Vlahos, Robert D. Brooks, John J. O’Leary, Doug A. Brooks, Stavros Selemidis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
mitochondria
endosome
reactive oxygen
NADPH oxidase
influenza A virus
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.870156/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.870156/full

Similar Items