DEX‐Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T‐Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy

DEX‐Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T‐Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy

Abstract T‐cell acute lymphoblastic leukemia (T‐ALL) is an aggressive malignant blood disorder with a high rate of relapse. Patients relapse as a result of minimal residual disease (MRD), which originates from residual T‐ALL cells in the bone marrow microenvironment (BMM). In the present study, it i...

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Bibliographic Details
Main Authors: Ruinan Jia, Tao Sun, Xin Zhao, Guosheng Li, Yuan Xia, Ying Zhou, Wěi Li, Wei Li, Daoxin Ma, Jingjing Ye, Min Ji, Chunyan Ji
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Advanced Science
Subjects:
adipogenesis
bone marrow mesenchymal stem cells (BMSCs)
chemotherapy
minimal residual disease (MRD)
T‐cell acute lymphoblastic leukemia (T‐ALL)
Online Access:https://doi.org/10.1002/advs.202205854

Internet

https://doi.org/10.1002/advs.202205854

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