Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids

Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids

Summary: Background: Epileptic (previously infantile) spasms is the most common epileptic encephalopathy occurring during infancy and is frequently associated with abnormal neurodevelopmental outcomes. Epileptic spasms have a diverse range of known (genetic, structural) and unknown aetiologies. Hig...

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Bibliographic Details
Main Authors: Jingya Yan, Kavitha Kothur, Emily A. Innes, Velda X. Han, Hannah F. Jones, Shrujna Patel, Erica Tsang, Richard Webster, Sachin Gupta, Christopher Troedson, Manoj P. Menezes, Jayne Antony, Simone Ardern-Holmes, Esther Tantsis, Shekeeb Mohammad, Louise Wienholt, Ananda S. Pires, Benjamin Heng, Gilles J. Guillemin, Anna Guller, Deepak Gill, Sushil Bandodkar, Russell C. Dale
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:EBioMedicine
Subjects:
Cerebrospinal fluid
Tryptophan-kynurenine pathway
Infantile spasms
Epileptic spasms
Metabolomics
Ketogenic diet
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422004625

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http://www.sciencedirect.com/science/article/pii/S2352396422004625

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