Alzheimer's Disease-like Alterations in Peripheral Cells from Presenilin-1 Transgenic Mice

Alzheimer's Disease-like Alterations in Peripheral Cells from Presenilin-1 Transgenic Mice

Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Expression of PS1 mutations in cell culture systems and in primary neurons from transgenic mice increases their vulnerability to cell death. Interestingly, enhanced vulnerability...

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Bibliographic Details
Main Authors: Anne Eckert, Katharina Schindowski, Silke Leutner, Christian Luckhaus, Nathalie Touchet, Christian Czech, Walter E. Müller
Format: Article
Language:English
Published: Elsevier 2001-04-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
presenilin-1
cell death
calcium
oxidative stress
lymphocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996100903784

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http://www.sciencedirect.com/science/article/pii/S0969996100903784

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