Crystal structure of the Ilheus virus helicase: implications for enzyme function and drug design

Crystal structure of the Ilheus virus helicase: implications for enzyme function and drug design

Abstract Background The Ilheus virus (ILHV) is an encephalitis associated arthropod-borne flavivirus. It was first identified in Ilheus City in the northeast Brazil before spreading to a wider geographic range. No specific vaccines or drugs are currently available for the treatment of ILHV infection...

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Bibliographic Details
Main Authors: De-Ping Wang, Mei-Yue Wang, Yong-Mei Li, Wen Shu, Wen Cui, Fang-Ying Jiang, Xin Zhou, Wen-Ming Wang, Ji-Min Cao
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Cell & Bioscience
Subjects:
Ilheus virus
NS3 helicase
Crystal structure
ATP hydrolysis
Molecular docking
Online Access:https://doi.org/10.1186/s13578-022-00777-8

Internet

https://doi.org/10.1186/s13578-022-00777-8

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