In Vitro Toxicity Studies of Bioactive Organosulfur Compounds from <i>Allium</i> spp. with Potential Application in the Agri-Food Industry: A Review
Organosulfur compounds (OSCs) are secondary metabolites produced by different <i>Allium</i> species which present important biological activities such as antimicrobial, antioxidant, anti-inflammatory antidiabetic, anticarcinogenic, antispasmodic, etc. In recent years, their use has been...
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MDPI AG
2022-08-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/17/2620 |
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| author | Antonio Cascajosa-Lira Pedro Andreo-Martínez Ana Isabel Prieto Alberto Baños Enrique Guillamón Angeles Jos Ana M. Cameán |
| author_facet | Antonio Cascajosa-Lira Pedro Andreo-Martínez Ana Isabel Prieto Alberto Baños Enrique Guillamón Angeles Jos Ana M. Cameán |
| author_sort | Antonio Cascajosa-Lira |
| collection | DOAJ |
| description | Organosulfur compounds (OSCs) are secondary metabolites produced by different <i>Allium</i> species which present important biological activities such as antimicrobial, antioxidant, anti-inflammatory antidiabetic, anticarcinogenic, antispasmodic, etc. In recent years, their use has been promoted in the agri-food industry as a substitute for synthetic preservatives, increasing potential accumulative exposure to consumers. Before their application in the food industry, it is necessary to pass a safety assessment as specified by the European Food Safety Authority (EFSA). This work reviews the scientific literature on OSCs regarding their in vitro toxicity evaluation following PRISMA guidelines for systematic reviews. Four electronic research databases were searched (Web of Science, Scopus, Science Database and PubMed) and a total of 43 works were selected according to predeterminate inclusion and exclusion criteria. Different data items and the risk of bias for each study were included. Currently, there are very few in vitro studies focused on investigating the potential toxicity of OSCs. Most research studies aimed to evaluate the cytotoxicity of OSCs to elucidate their antiproliferative effects focusing on their therapeutic aspects using cancer cell lines as the main experimental model. The results showed that diallyl disulfide (DADS) is the compound most studied, followed by diallyl trisulfide (DATS), diallyl sulfide (DAS), Allicin and Ajoene. Only 4 studies have been performed specifically to explore the safety of OSCs for agri-food applications, and genotoxicity studies are limited. More toxicity studies of OSCs are necessary to ensure consumers safety and should mainly be focused on the evaluation of genotoxicity and long-term toxicity effects. |
| first_indexed | 2024-03-10T01:49:21Z |
| format | Article |
| id | doaj.art-a99e4f329f5b45829cef9be8132126b8 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T01:49:21Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-a99e4f329f5b45829cef9be8132126b82023-11-23T13:08:24ZengMDPI AGFoods2304-81582022-08-011117262010.3390/foods11172620In Vitro Toxicity Studies of Bioactive Organosulfur Compounds from <i>Allium</i> spp. with Potential Application in the Agri-Food Industry: A ReviewAntonio Cascajosa-Lira0Pedro Andreo-Martínez1Ana Isabel Prieto2Alberto Baños3Enrique Guillamón4Angeles Jos5Ana M. Cameán6Área de Toxicología, Facultad de Farmacia, Universidad de Sevilla, Profesor García González n 2, 41012 Seville, SpainDepartment of Agricultural Chemistry, Faculty of Chemistry, Campus of Espinardo, University of Murcia, 30100 Murcia, SpainÁrea de Toxicología, Facultad de Farmacia, Universidad de Sevilla, Profesor García González n 2, 41012 Seville, SpainDMC Research Center, Camino de Jayena, 82, 18620 Alhendín, SpainDMC Research Center, Camino de Jayena, 82, 18620 Alhendín, SpainÁrea de Toxicología, Facultad de Farmacia, Universidad de Sevilla, Profesor García González n 2, 41012 Seville, SpainÁrea de Toxicología, Facultad de Farmacia, Universidad de Sevilla, Profesor García González n 2, 41012 Seville, SpainOrganosulfur compounds (OSCs) are secondary metabolites produced by different <i>Allium</i> species which present important biological activities such as antimicrobial, antioxidant, anti-inflammatory antidiabetic, anticarcinogenic, antispasmodic, etc. In recent years, their use has been promoted in the agri-food industry as a substitute for synthetic preservatives, increasing potential accumulative exposure to consumers. Before their application in the food industry, it is necessary to pass a safety assessment as specified by the European Food Safety Authority (EFSA). This work reviews the scientific literature on OSCs regarding their in vitro toxicity evaluation following PRISMA guidelines for systematic reviews. Four electronic research databases were searched (Web of Science, Scopus, Science Database and PubMed) and a total of 43 works were selected according to predeterminate inclusion and exclusion criteria. Different data items and the risk of bias for each study were included. Currently, there are very few in vitro studies focused on investigating the potential toxicity of OSCs. Most research studies aimed to evaluate the cytotoxicity of OSCs to elucidate their antiproliferative effects focusing on their therapeutic aspects using cancer cell lines as the main experimental model. The results showed that diallyl disulfide (DADS) is the compound most studied, followed by diallyl trisulfide (DATS), diallyl sulfide (DAS), Allicin and Ajoene. Only 4 studies have been performed specifically to explore the safety of OSCs for agri-food applications, and genotoxicity studies are limited. More toxicity studies of OSCs are necessary to ensure consumers safety and should mainly be focused on the evaluation of genotoxicity and long-term toxicity effects.https://www.mdpi.com/2304-8158/11/17/2620<i>Allium</i>natural additivebioactive organosulfur compoundstoxicityin vitro |
| spellingShingle | Antonio Cascajosa-Lira Pedro Andreo-Martínez Ana Isabel Prieto Alberto Baños Enrique Guillamón Angeles Jos Ana M. Cameán In Vitro Toxicity Studies of Bioactive Organosulfur Compounds from <i>Allium</i> spp. with Potential Application in the Agri-Food Industry: A Review Foods <i>Allium</i> natural additive bioactive organosulfur compounds toxicity in vitro |
| title | In Vitro Toxicity Studies of Bioactive Organosulfur Compounds from <i>Allium</i> spp. with Potential Application in the Agri-Food Industry: A Review |
| title_full | In Vitro Toxicity Studies of Bioactive Organosulfur Compounds from <i>Allium</i> spp. with Potential Application in the Agri-Food Industry: A Review |
| title_fullStr | In Vitro Toxicity Studies of Bioactive Organosulfur Compounds from <i>Allium</i> spp. with Potential Application in the Agri-Food Industry: A Review |
| title_full_unstemmed | In Vitro Toxicity Studies of Bioactive Organosulfur Compounds from <i>Allium</i> spp. with Potential Application in the Agri-Food Industry: A Review |
| title_short | In Vitro Toxicity Studies of Bioactive Organosulfur Compounds from <i>Allium</i> spp. with Potential Application in the Agri-Food Industry: A Review |
| title_sort | in vitro toxicity studies of bioactive organosulfur compounds from i allium i spp with potential application in the agri food industry a review |
| topic | <i>Allium</i> natural additive bioactive organosulfur compounds toxicity in vitro |
| url | https://www.mdpi.com/2304-8158/11/17/2620 |
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