Mechanical Stretch-Induced NLRP3 Inflammasome Expression on Human Annulus Fibrosus Cells Modulated by Endoplasmic Reticulum Stress

Mechanical Stretch-Induced NLRP3 Inflammasome Expression on Human Annulus Fibrosus Cells Modulated by Endoplasmic Reticulum Stress

Excessive mechanical loading is a major cause of spinal degeneration, typically originating from a tear in the annulus fibrosus (AF). Endoplasmic reticulum (ER) stress and NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome have been implicated in the pathogenesis of intervertebral...

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Bibliographic Details
Main Authors: Hsin-I Chang, Cheng-Nan Chen, Kuo-Yuan Huang
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
annulus fibrosus
mechanical stretch
endoplasmic reticulum stress
NLRP3 inflammasome
reactive oxygen species
intervertebral disc degeneration
Online Access:https://www.mdpi.com/1422-0067/23/14/7951

Internet

https://www.mdpi.com/1422-0067/23/14/7951

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