Predictive functional, statistical and structural analysis of CSNK2A1 and CSNK2B variants linked to neurodevelopmental diseases

Predictive functional, statistical and structural analysis of CSNK2A1 and CSNK2B variants linked to neurodevelopmental diseases

Okur-Chung Neurodevelopmental Syndrome (OCNDS) and Poirier-Bienvenu Neurodevelopmental Syndrome (POBINDS) were recently identified as rare neurodevelopmental disorders. OCNDS and POBINDS are associated with heterozygous mutations in the CSNK2A1 and CSNK2B genes which encode CK2α, a serine/threonine...

Full description

Bibliographic Details
Main Authors: Prasida Unni, Jack Friend, Janice Weinberg, Volkan Okur, Jennifer Hochscherf, Isabel Dominguez
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
CK2α
CK2β
protein kinase CK2
Okur-Chung neurodevelopmental syndrome (OCNDS)
Poirier-Bienvenu neurodevelopmental syndrome (POBINDS)
autism spectrum disorder (ASD)
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.851547/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.851547/full

Similar Items