Human Growth Hormone Delivery with a Microneedle Transdermal System: Preclinical Formulation, Stability, Delivery and PK of Therapeutically Relevant Doses

Human Growth Hormone Delivery with a Microneedle Transdermal System: Preclinical Formulation, Stability, Delivery and PK of Therapeutically Relevant Doses

This study evaluated the feasibility of coating formulated recombinant human growth hormone (rhGH) on a titanium microneedle transdermal delivery system, Zosano Pharma (ZP)-hGH, and assessed preclinical patch delivery performance. Formulation rheology and surface activity were assessed by viscometry...

Full description

Bibliographic Details
Main Authors: Mahmoud Ameri, Miryam Kadkhodayan, Joe Nguyen, Joseph A. Bravo, Rebeca Su, Kenneth Chan, Ahmad Samiee, Peter E. Daddona
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Pharmaceutics
Subjects:
human growth hormone
rhGH
stability
transdermal microneedle patch
pharmacokinetics
Online Access:http://www.mdpi.com/1999-4923/6/2/220

Internet

http://www.mdpi.com/1999-4923/6/2/220

Similar Items