Derrone Targeting the TGF Type 1 Receptor Kinase Improves Bleomycin-Mediated Pulmonary Fibrosis through Inhibition of Smad Signaling Pathway

Derrone Targeting the TGF Type 1 Receptor Kinase Improves Bleomycin-Mediated Pulmonary Fibrosis through Inhibition of Smad Signaling Pathway

Transforming growth factor-β (TGF-β) has a strong impact on the pathogenesis of pulmonary fibrosis. Therefore, in this study, we investigated whether derrone promotes anti-fibrotic effects on TGF-β1-stimulated MRC-5 lung fibroblast cells and bleomycin-induced lung fibrosis. Long-term treatment with...

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Bibliographic Details
Main Authors: Ilandarage Menu Neelaka Molagoda, Sobarathne Senel Sanjaya, Kyoung Tae Lee, Yung Hyun Choi, Joyce H. Lee, Mi-Hwa Lee, Chang-Hee Kang, Chang-Min Lee, Gi-Young Kim
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
derrone
pulmonary fibrosis
TGF-β1
TGF type 1 receptor kinase
Smad2/3
Online Access:https://www.mdpi.com/1422-0067/24/8/7265

Internet

https://www.mdpi.com/1422-0067/24/8/7265

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