Non-Lethal Doses of RSL3 Impair Microvascular Endothelial Barrier through Degradation of Sphingosie-1-Phosphate Receptor 1 and Cytoskeletal Arrangement in A Ferroptosis-Independent Manner

Non-Lethal Doses of RSL3 Impair Microvascular Endothelial Barrier through Degradation of Sphingosie-1-Phosphate Receptor 1 and Cytoskeletal Arrangement in A Ferroptosis-Independent Manner

The excess microvascular endothelial permeability is a hallmark of acute inflammatory diseases. Maintenance of microvascular integrity is critical to preventing leakage of vascular components into the surrounding tissues. Sphingosine-1-phosphate (S1P) is an active lysophospholipid that enhances the...

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Bibliographic Details
Main Authors: Boina Baoyinna, Jiaxing Miao, Patrick J. Oliver, Qinmao Ye, Nargis Shaheen, Timothy Kalin, Jinshan He, Narasimham L. Parinandi, Yutong Zhao, Jing Zhao
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biomedicines
Subjects:
RSL3
S1PR1
endothelial permeability
cytoskeletal arrangement
protein degradation
Online Access:https://www.mdpi.com/2227-9059/11/9/2451

Internet

https://www.mdpi.com/2227-9059/11/9/2451

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