Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Abstract Background In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and a...

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Xehetasun bibliografikoak
Egile Nagusiak: Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca, Ciro Isidoro
Formatua: Artikulua
Hizkuntza:English
Argitaratua: BMC 2019-05-01
Saila:Cell Communication and Signaling
Gaiak:
Autophagy
Starvation
mTORC1
Lysosome
TFEB
Protein translation
Sarrera elektronikoa:http://link.springer.com/article/10.1186/s12964-019-0354-2

Internet

http://link.springer.com/article/10.1186/s12964-019-0354-2

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