Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Abstract Background In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and a...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca, Ciro Isidoro
Μορφή:	Άρθρο
Γλώσσα:	English
Έκδοση:	BMC 2019-05-01
Σειρά:	Cell Communication and Signaling
Θέματα:	Autophagy Starvation mTORC1 Lysosome TFEB Protein translation
Διαθέσιμο Online:	http://link.springer.com/article/10.1186/s12964-019-0354-2

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