Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Abstract Background In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and a...

書目詳細資料
Main Authors:	Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca, Ciro Isidoro
格式:	Article
語言:	English
出版:	BMC 2019-05-01
叢編:	Cell Communication and Signaling
主題:	Autophagy Starvation mTORC1 Lysosome TFEB Protein translation
在線閱讀:	http://link.springer.com/article/10.1186/s12964-019-0354-2

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