Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Abstract Background In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and a...

詳細記述

書誌詳細
主要な著者: Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca, Ciro Isidoro
フォーマット: 論文
言語:English
出版事項: BMC 2019-05-01
シリーズ:Cell Communication and Signaling
主題:
Autophagy
Starvation
mTORC1
Lysosome
TFEB
Protein translation
オンライン･アクセス:http://link.springer.com/article/10.1186/s12964-019-0354-2

インターネット

http://link.springer.com/article/10.1186/s12964-019-0354-2

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