Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Abstract Background In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and a...

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Detaylı Bibliyografya
Asıl Yazarlar: Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca, Ciro Isidoro
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: BMC 2019-05-01
Seri Bilgileri:Cell Communication and Signaling
Konular:
Autophagy
Starvation
mTORC1
Lysosome
TFEB
Protein translation
Online Erişim:http://link.springer.com/article/10.1186/s12964-019-0354-2

Internet

http://link.springer.com/article/10.1186/s12964-019-0354-2

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