PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma

PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma

Summary: The adhesion G-protein-coupled receptor GPR133 (ADGRD1) supports growth of the brain malignancy glioblastoma. How the extracellular interactome of GPR133 in glioblastoma modulates signaling remains unknown. Here, we use affinity proteomics to identify the transmembrane protein PTK7 as an ex...

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Bibliographic Details
Main Authors: Joshua D. Frenster, Hediye Erdjument-Bromage, Gabriele Stephan, Niklas Ravn-Boess, Shuai Wang, Wenke Liu, Devin Bready, Jordan Wilcox, Björn Kieslich, Manuel Jankovic, Caroline Wilde, Susanne Horn, Norbert Sträter, Ines Liebscher, Torsten Schöneberg, David Fenyo, Thomas A. Neubert, Dimitris G. Placantonakis
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723006903

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http://www.sciencedirect.com/science/article/pii/S2211124723006903

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