Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virus.

Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virus.

Venezuelan equine encephalitis virus (VEEV) is a positively-stranded RNA arbovirus of the genus Alphavirus that causes encephalitis in humans. Cynomolgus macaques are a relevant model of the human disease caused by VEEV and are useful in exploring pathogenic mechanisms and the host response to VEEV...

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Bibliographic Details
Main Authors: Henry Ma, Joseph R Albe, Theron Gilliland, Cynthia M McMillen, Christina L Gardner, Devin A Boyles, Emily L Cottle, Matthew D Dunn, Jeneveve D Lundy, Noah Salama, Katherine J O'Malley, Ivona Pandrea, Tobias Teichert, Stacey Barrick, William B Klimstra, Amy L Hartman, Douglas S Reed
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009946

Internet

https://doi.org/10.1371/journal.ppat.1009946

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