Serum Neutralizing and Enhancing Effects on African Swine Fever Virus Infectivity in Adherent Pig PBMC

Serum Neutralizing and Enhancing Effects on African Swine Fever Virus Infectivity in Adherent Pig PBMC

African swine fever virus (ASFV) causes hemorrhagic fever with mortality rates of up to 100% in domestic pigs. Currently, there are no commercial vaccines for the disease. Only some live-attenuated viruses have been able to protect pigs from ASFV infection. The immune mechanisms involved in the prot...

Full description

Bibliographic Details
Main Authors:	Jessica A. Canter, Theresa Aponte, Elizabeth Ramirez-Medina, Sarah Pruitt, Douglas P. Gladue, Manuel V. Borca, James J. Zhu
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Viruses
Subjects:	African swine fever virus (ASFV) hyperimmune serum virus neutralization flow cytometry monocyte-derived macrophage extracellular virions
Online Access:	https://www.mdpi.com/1999-4915/14/6/1249

Similar Items

Deletion of African Swine Fever Virus Histone-like Protein, A104R from the Georgia Isolate Drastically Reduces Virus Virulence in Domestic Pigs
by: Elizabeth Ramirez-Medina, et al.
Published: (2022-05-01)

The C962R ORF of African Swine Fever Strain Georgia Is Non-Essential and Not Required for Virulence in Swine
by: Elizabeth. Ramirez-Medina, et al.
Published: (2020-06-01)

X69R Is a Non-Essential Gene That, When Deleted from African Swine Fever, Does Not Affect Virulence in Swine
by: Elizabeth Ramirez-Medina, et al.
Published: (2020-08-01)

ASFV-G-∆I177L as an Effective Oral Nasal Vaccine against the Eurasia Strain of Africa Swine Fever
by: Manuel V. Borca, et al.
Published: (2021-04-01)

Deletion of the EP296R Gene from the Genome of Highly Virulent African Swine Fever Virus Georgia 2010 Does Not Affect Virus Replication or Virulence in Domestic Pigs
by: Elizabeth A. Vuono, et al.
Published: (2022-07-01)

Evaluation in Swine of a Recombinant Georgia 2010 African Swine Fever Virus Lacking the I8L Gene
by: Elizabeth Vuono, et al.
Published: (2020-12-01)

Evaluation in Swine of a Recombinant African Swine Fever Virus Lacking the MGF-360-1L Gene
by: Elizabeth Ramirez-Medina, et al.
Published: (2020-10-01)

Evaluation of the Deletion of the African Swine Fever Virus Gene <i>O174L</i> from the Genome of the Georgia Isolate
by: Elizabeth Ramirez-Medina, et al.
Published: (2023-10-01)

The Presence of Virus Neutralizing Antibodies Is Highly Associated with Protection against Virulent Challenge in Domestic Pigs Immunized with ASFV live Attenuated Vaccine Candidates
by: Ediane B. Silva, et al.
Published: (2022-11-01)

Deletion of an African Swine Fever Virus ATP-Dependent RNA Helicase <i>QP509L</i> from the Highly Virulent Georgia 2010 Strain Does Not Affect Replication or Virulence
by: Elizabeth Ramirez-Medina, et al.
Published: (2022-11-01)

Differential Effect of the Deletion of African Swine Fever Virus Virulence-Associated Genes in the Induction of Attenuation of the Highly Virulent Georgia Strain
by: Elizabeth Ramirez-Medina, et al.
Published: (2019-07-01)

Epidemiological Characterization of African Swine Fever Dynamics in Ukraine, 2012–2023
by: Maksym Bezymennyi, et al.
Published: (2023-06-01)

African Swine Fever Vaccinology: The Biological Challenges from Immunological Perspectives
by: James J. Zhu
Published: (2022-09-01)

Deletion of the <i>H240R</i> Gene in African Swine Fever Virus Partially Reduces Virus Virulence in Swine
by: Elizabeth Ramirez-Medina, et al.
Published: (2023-06-01)

Deletion of the ASFV dUTPase Gene <i>E165R</i> from the Genome of Highly Virulent African Swine Fever Virus Georgia 2010 Does Not Affect Virus Replication or Virulence in Domestic Pigs
by: Elizabeth A. Vuono, et al.
Published: (2022-06-01)

Evaluation of an ASFV RNA Helicase Gene A859L for Virus Replication and Swine Virulence
by: Elizabeth Ramirez-Medina, et al.
Published: (2021-12-01)

Inhibition of African swine fever virus replication by β-glucan
by: Truong Anh Duc, et al.
Published: (2022-12-01)

ASFV Gene A151R Is Involved in the Process of Virulence in Domestic Swine
by: Elizabeth Ramirez-Medina, et al.
Published: (2022-08-01)

Recombinant ASF Live Attenuated Virus Strains as Experimental Vaccine Candidates
by: Douglas P. Gladue, et al.
Published: (2022-04-01)

The 2022 Outbreaks of African Swine Fever Virus Demonstrate the First Report of Genotype II in Ghana
by: Edward Spinard, et al.
Published: (2023-08-01)

Evaluation of the Function of ASFV Gene E66L in the Process of Virus Replication and Virulence in Swine
by: Elizabeth Ramirez-Medina, et al.
Published: (2023-02-01)

Evaluation of the Function of the ASFV <i>KP177R</i> Gene, Encoding for Structural Protein p22, in the Process of Virus Replication and in Swine Virulence
by: Elizabeth A. Vuono, et al.
Published: (2021-05-01)

Viricidal activity of several disinfectants against African swine fever virus
by: Cheng-gang JIANG, et al.
Published: (2021-11-01)

Proteome Analysis of Swine Macrophages after Infection with Two Genotype II African Swine Fever Isolates of Different Pathogenicity
by: Elisabeth Wöhnke, et al.
Published: (2022-09-01)

A Re-Evaluation of African Swine Fever Genotypes Based on p72 Sequences Reveals the Existence of Only Six Distinct p72 Groups
by: Edward Spinard, et al.
Published: (2023-11-01)

Prospects for the application of infectious virus detection technology based on propidium monoazide in African swine fever management
by: Dexin Zeng, et al.
Published: (2022-09-01)

Analysis of gene expression in monocytes of immunized pigs after infection with homologous or heterologous African swine fever virus
by: Natalia Kholod, et al.
Published: (2022-08-01)

Development of a multiplex qRT-PCR assay for detection of classical swine fever virus, African swine fever virus, and Erysipelothrix rhusiopathiae
by: Liang Zhao, et al.
Published: (2023-05-01)

The MGF360-16R ORF of African Swine Fever Virus Strain Georgia Encodes for a Nonessential Gene That Interacts with Host Proteins SERTAD3 and SDCBP
by: Elizabeth Ramírez-Medina, et al.
Published: (2020-01-01)

Development and In Vivo Evaluation of a MGF110-1L Deletion Mutant in African Swine Fever Strain Georgia
by: Elizabeth Ramirez-Medina, et al.
Published: (2021-02-01)

A Method for the Analysis of African Swine Fever by Viral Metagenomic Sequencing
by: ChiHai Ji, et al.
Published: (2021-11-01)

A porcine kidney-derived clonal cell line with clear genetic annotation is highly susceptible to African swine fever virus
by: Hua Cao, et al.
Published: (2024-04-01)

Detection of African Swine Fever Virus from Wild Boar, Singapore, 2023
by: Eileen Y. Koh, et al.
Published: (2023-12-01)

African swine fever vaccines: a promising work still in progress
by: Laia Bosch-Camós, et al.
Published: (2020-07-01)

Development of a Blocking Enzyme-Linked Immunosorbent Assay for Detection of Antibodies against African Swine Fever Virus
by: Fangfeng Yuan, et al.
Published: (2021-06-01)

Deleting the C84L Gene from the Virulent African Swine Fever Virus SY18 Does Not Affect Its Replication in Porcine Primary Macrophages but Reduces Its Virulence in Swine
by: Jinjin Yang, et al.
Published: (2024-01-01)

African Swine Fever Virus, Siberia, Russia, 2017
by: Denis Kolbasov, et al.
Published: (2018-04-01)

Extension of Sylvatic Circulation of African Swine Fever Virus in Extralimital Warthogs in South Africa
by: Anthony F. Craig, et al.
Published: (2021-11-01)

Swine Host Protein Coiled-Coil Domain-Containing 115 (CCDC115) Interacts with Classical Swine Fever Virus Structural Glycoprotein E2 during Virus Replication
by: Elizabeth A. Vuono, et al.
Published: (2020-03-01)

Problems of specific prevention of African swine fever
by: Natalia N. Vlasova, et al.
Published: (2022-09-01)