ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation

Tumour growth is not solely driven by tumour cell-intrinsic mechanisms, but also depends on paracrine signals provided by the tumour micro-environment. These signals comprise cytokines and growth factors that are synthesized as trans-membrane proteins and need to be liberated by limited proteolysis...

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Bibliographic Details
Main Authors: Neele Schumacher, Stefan Rose-John, Dirk Schmidt-Arras
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/14/5133