ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation
Tumour growth is not solely driven by tumour cell-intrinsic mechanisms, but also depends on paracrine signals provided by the tumour micro-environment. These signals comprise cytokines and growth factors that are synthesized as trans-membrane proteins and need to be liberated by limited proteolysis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/14/5133 |
| _version_ | 1797561894064619520 |
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| author | Neele Schumacher Stefan Rose-John Dirk Schmidt-Arras |
| author_facet | Neele Schumacher Stefan Rose-John Dirk Schmidt-Arras |
| author_sort | Neele Schumacher |
| collection | DOAJ |
| description | Tumour growth is not solely driven by tumour cell-intrinsic mechanisms, but also depends on paracrine signals provided by the tumour micro-environment. These signals comprise cytokines and growth factors that are synthesized as trans-membrane proteins and need to be liberated by limited proteolysis also termed ectodomain shedding. Members of the family of A disintegrin and metalloproteases (ADAM) are major mediators of ectodomain shedding and therefore initiators of paracrine signal transduction. In this review, we summarize the current knowledge on how ADAM proteases on tumour cells but also on cells of the tumour micro-environment contribute to the formation of gastrointestinal tumours, and discuss how these processes can be exploited pharmacologically. |
| first_indexed | 2024-03-10T18:21:03Z |
| format | Article |
| id | doaj.art-a9b10c40664b4566a001c952dd362d7c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:21:03Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a9b10c40664b4566a001c952dd362d7c2023-11-20T07:21:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012114513310.3390/ijms21145133ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer FormationNeele Schumacher0Stefan Rose-John1Dirk Schmidt-Arras2Institute of Biochemistry, Christian-Albrechts-University, 24118 Kiel, GermanyInstitute of Biochemistry, Christian-Albrechts-University, 24118 Kiel, GermanyInstitute of Biochemistry, Christian-Albrechts-University, 24118 Kiel, GermanyTumour growth is not solely driven by tumour cell-intrinsic mechanisms, but also depends on paracrine signals provided by the tumour micro-environment. These signals comprise cytokines and growth factors that are synthesized as trans-membrane proteins and need to be liberated by limited proteolysis also termed ectodomain shedding. Members of the family of A disintegrin and metalloproteases (ADAM) are major mediators of ectodomain shedding and therefore initiators of paracrine signal transduction. In this review, we summarize the current knowledge on how ADAM proteases on tumour cells but also on cells of the tumour micro-environment contribute to the formation of gastrointestinal tumours, and discuss how these processes can be exploited pharmacologically.https://www.mdpi.com/1422-0067/21/14/5133ADAMproteaseEGFRtumour micro-environmentNotchIL-6 |
| spellingShingle | Neele Schumacher Stefan Rose-John Dirk Schmidt-Arras ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation International Journal of Molecular Sciences ADAM protease EGFR tumour micro-environment Notch IL-6 |
| title | ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation |
| title_full | ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation |
| title_fullStr | ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation |
| title_full_unstemmed | ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation |
| title_short | ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation |
| title_sort | adam mediated signalling pathways in gastrointestinal cancer formation |
| topic | ADAM protease EGFR tumour micro-environment Notch IL-6 |
| url | https://www.mdpi.com/1422-0067/21/14/5133 |
| work_keys_str_mv | AT neeleschumacher adammediatedsignallingpathwaysingastrointestinalcancerformation AT stefanrosejohn adammediatedsignallingpathwaysingastrointestinalcancerformation AT dirkschmidtarras adammediatedsignallingpathwaysingastrointestinalcancerformation |