The crystal structure of the FAM134B–GABARAP complex provides mechanistic insights into the selective binding of FAM134 to the GABARAP subfamily

The crystal structure of the FAM134B–GABARAP complex provides mechanistic insights into the selective binding of FAM134 to the GABARAP subfamily

The mammalian Atg8 family (Atg8s proteins) consists of two subfamilies: GABARAP and LC3. All members can bind to the LC3‐interacting region (LIR) or Atg8‐interacting motif and participate in multiple steps of autophagy. The endoplasmic reticulum (ER) autophagy receptor FAM134B contains an LIR motif...

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Bibliographic Details
Main Authors: Junfeng Zhao, Zhiwei Li, Jianchao Li
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:FEBS Open Bio
Subjects:
Atg8
autophagy
FAM134B
GABARAP
LC3‐interacting region/Atg8‐interacting motif
Online Access:https://doi.org/10.1002/2211-5463.13340

Internet

https://doi.org/10.1002/2211-5463.13340

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