Functional characterization of CDK10 and cyclin M truncated variants causing severe developmental disorders

Functional characterization of CDK10 and cyclin M truncated variants causing severe developmental disorders

Abstract Background CDK10 is a poorly known cyclin M (CycM)‐dependent kinase. Loss‐of‐function mutations in the genes encoding CycM or CDK10 cause, respectively, STAR or Al Kaissi syndromes, which present a constellation of malformations and dysfunctions. Most reported mutations abolish gene express...

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Bibliographic Details
Main Authors: Thomas Robert, Anne‐Catherine Dock‐Bregeon, Pierre Colas
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
Al Kaissi syndrome
CDK10
cyclin M
interaction profiling
protein kinase
STAR syndrome
Online Access:https://doi.org/10.1002/mgg3.1782

Internet

https://doi.org/10.1002/mgg3.1782

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