Zfp57 mutant ES cell lines directly derived from blastocysts

Zfp57 is a master regulator of genomic imprinting in mouse embryos. To further test its functions, we have derived multiple Zfp57 mutant ES clones directly from mouse blastocysts. Indeed, we found DNA methylation imprint was lost at most examined imprinting control regions in these Zfp57 mutant ES c...

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Detalhes bibliográficos
Main Authors: Ho-Tak Lau, Lizhi Liu, Xiajun Li
Formato: Artigo
Idioma:English
Publicado em: Elsevier 2016-03-01
Colecção:Stem Cell Research
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1873506116000027