A Novel, Comprehensive A129 Mouse Model for Investigating Dengue Vaccines and Evaluating Pathogenesis

A Novel, Comprehensive A129 Mouse Model for Investigating Dengue Vaccines and Evaluating Pathogenesis

In search of a mouse model for use in evaluating dengue vaccines, we assessed A129 mice that lacked IFN-α/β receptors, rendering them susceptible to dengue virus (DENV) infection. To our knowledge, no reports have evaluated dengue vaccine efficiency using A129 mice. A129 mice were given a single int...

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Bibliographic Details
Main Authors: Mya Myat Ngwe Tun, Khine Mya Nwe, Jean Claude Balingit, Yuki Takamatsu, Shingo Inoue, Basu Dev Pandey, Takeshi Urano, Michinori Kohara, Kyoko Tsukiyama-Kohara, Kouichi Morita
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Vaccines
Subjects:
A129 mouse
Dengvaxia vaccine
dengue virus
neutralization antibody
viral loads
Online Access:https://www.mdpi.com/2076-393X/11/12/1857

Internet

https://www.mdpi.com/2076-393X/11/12/1857

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