The Disorazole Z Family of Highly Potent Anticancer Natural Products from Sorangium cellulosum: Structure, Bioactivity, Biosynthesis, and Heterologous Expression

The Disorazole Z Family of Highly Potent Anticancer Natural Products from Sorangium cellulosum: Structure, Bioactivity, Biosynthesis, and Heterologous Expression

ABSTRACT Myxobacteria serve as a treasure trove of secondary metabolites. During our ongoing search for bioactive natural products, a novel subclass of disorazoles termed disorazole Z was discovered. Ten disorazole Z family members were purified from a large-scale fermentation of the myxobacterium S...

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Bibliographic Details
Main Authors: Yunsheng Gao, Joy Birkelbach, Chengzhang Fu, Jennifer Herrmann, Herbert Irschik, Bernd Morgenstern, Kerstin Hirschfelder, Ruijuan Li, Youming Zhang, Rolf Jansen, Rolf Müller
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
myxobacteria
secondary metabolites
disorazole Z
anticancer natural products
biosynthetic gene cluster
direct cloning
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00730-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00730-23

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