Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine‐Altering Variants

Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine‐Altering Variants

Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most prevalent monogenic cerebral small‐vessel disease. Phenotype variability in CADASIL suggests the possible role of genetic modifiers. We aimed to investigate the contributions o...

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Bibliographic Details
Main Authors: Yu‐Wen Cheng, Yi‐Chu Liao, Chih‐Hao Chen, Chih‐Ping Chung, Cathy S. J. Fann, Chien‐Ching Chang, Yi‐Chung Lee, Sung‐Chun Tang
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
APOE
CADASIL
cerebral small‐vessel disease
NOTCH3
vascular cognitive impairment
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.032689

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.123.032689

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