Rhein attenuates angiotensin II-induced cardiac remodeling by modulating AMPK–FGF23 signaling

Rhein attenuates angiotensin II-induced cardiac remodeling by modulating AMPK–FGF23 signaling

Abstract Background Increasing evidence indicates that myocardial oxidative injury plays a crucial role in the pathophysiology of cardiac hypertrophy (CH) and heart failure (HF). The active component of rhubarb, rhein exerts significant actions on oxidative stress and inflammation. Nonetheless, its...

Full description

Bibliographic Details
Main Authors: Wei Lu, Hongqiao Zhu, Jiawen Wu, Sheng Liao, Guobing Cheng, Xiaoyang Li
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Translational Medicine
Subjects:
Rhein
Cardiac remodeling
ROS
AMPK
FGF23
Online Access:https://doi.org/10.1186/s12967-022-03482-9

Internet

https://doi.org/10.1186/s12967-022-03482-9

Similar Items