A convenient enantioselective decarboxylative aldol reaction to access chiral α-hydroxy esters using β-keto acids

We show a convenient decarboxylative aldol process using a scandium catalyst and a PYBOX ligand to generate a series of highly functionalized chiral α-hydroxy esters. The protocol tolerates a broad range of β-keto acids with inactivated aromatic and aliphatic α-keto esters. The possible mechanism is...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Zhiqiang Duan, Jianlin Han, Ping Qian, Zirui Zhang, Yi Wang, Yi Pan
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Beilstein-Institut 2014-04-01
Cyfres:Beilstein Journal of Organic Chemistry
Pynciau:
Mynediad Ar-lein:https://doi.org/10.3762/bjoc.10.95