A convenient enantioselective decarboxylative aldol reaction to access chiral α-hydroxy esters using β-keto acids
We show a convenient decarboxylative aldol process using a scandium catalyst and a PYBOX ligand to generate a series of highly functionalized chiral α-hydroxy esters. The protocol tolerates a broad range of β-keto acids with inactivated aromatic and aliphatic α-keto esters. The possible mechanism is...
Prif Awduron: | , , , , , |
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Fformat: | Erthygl |
Iaith: | English |
Cyhoeddwyd: |
Beilstein-Institut
2014-04-01
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Cyfres: | Beilstein Journal of Organic Chemistry |
Pynciau: | |
Mynediad Ar-lein: | https://doi.org/10.3762/bjoc.10.95 |