SWATH-MS insights on sodium butyrate effect on mAbs production and redox homeostasis in CHO cells

Abstract Sodium butyrate (NaBu), well-known as a histone deacetylase inhibitor and for its capacity to impede cell growth, can enhance the production of a specific protein, such as an antibody, in recombinant Chinese hamster ovary (CHO) cell cultures. In this study, two CHO cell lines, namely K1 and...

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Main Authors: Mauro Galli, Lillian Chia-Yi Liu, Kae Hwan Sim, Yee Jiun Kok, Katherine Wongtrakul-Kish, Terry Nguyen-Khuong, Stephen Tate, Xuezhi Bi
格式: 文件
语言:English
出版: SpringerOpen 2024-12-01
丛编:AMB Express
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在线阅读:https://doi.org/10.1186/s13568-024-01807-z