Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells

Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells

IntroductionThe enhanced β-cell senescence that accompanies insulin resistance and aging contributes to cellular dysfunction and loss of transcriptional identity leading to type 2 diabetes (T2D). While senescence is among the 12 recognized hallmarks of aging, its relation to other hallmarks includin...

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Bibliographic Details
Main Authors: Kanako Iwasaki, Benjamin Lalani, Jiho Kahng, Priscila Carapeto, Stephanie Sanjines, Francesko Hela, Cristian Abarca, Tadataka Tsuji, Justin Darcy, Andrzej Bartke, Yu-Hua Tseng, Rohit N. Kulkarni, Cristina Aguayo-Mazzucato
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Endocrinology
Subjects:
senescence
SASP
IGF-1
insulin
Dwarf
diabetes mellitus
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1203534/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1203534/full

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