MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling

MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling

Mesenchymal stromal cells (MSCs) contribute to the microenvironment regulating normal and malignant hematopoiesis, and thus may support subpopulations of cancer cells to escape therapeutic pressure. Here, we engineered bone marrow MSCs to express a synthetic CD19-sensor receptor to detect and displa...

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Bibliographic Details
Main Authors: Yun Huang, Aneta Drakul, Jasmeet Sidhu, Kerstin K. Rauwolf, James Kim, Beat Bornhauser, Jean-Pierre Bourquin
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:SLAS Discovery
Subjects:
Biosensor
Synthetic Notch receptor
Mesenchymal stromal cell
Leukemia
Ex vivo drug screen
Drug synergy
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555223000618

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http://www.sciencedirect.com/science/article/pii/S2472555223000618

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