TNFα inhibitor C87 sensitizes EGFRvIII transfected glioblastoma cells to gefitinib by a concurrent blockade of TNFα signaling

TNFα inhibitor C87 sensitizes EGFRvIII transfected glioblastoma cells to gefitinib by a concurrent blockade of TNFα signaling

<b>Objective</b> More than half of human glioblastomas show <i>EGFR</i> gene amplification and mutation, but EGFR inhibitors have not been effective in treating EGFR-positive glioblastoma patients. The mechanism behind this type of primary resistance is not well understood. T...

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Bibliographic Details
Main Authors: Li Ma, Chunhua She, Qian Shi, Qiang Yin, Xinxin Ji, Yongrong Wang, Yulong Fan, Xinyao Kong, Peng Li, Zengfeng Sun, Xiaohui Zhang, Zhen Zhang, Jian Wang, Tong Wang, Yuanfu Xu, Wenliang Li
Format: Article
Language:English
Published: China Anti-Cancer Association 2019-09-01
Series:Cancer Biology & Medicine
Subjects:
Glioblastoma
EGFR
TNFα
inhibitor
drug resistance
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1458

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/1458

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