Regulatory T cell enhancement in adults with cystic fibrosis receiving Elexacaftor/Tezacaftor/Ivacaftor therapy

Regulatory T cell enhancement in adults with cystic fibrosis receiving Elexacaftor/Tezacaftor/Ivacaftor therapy

IntroductionCystic fibrosis (CF), especially CF lung disease, is characterized by chronic infection, immune dysfunction including impairment of regulatory T cells (Tregs) and an exaggerated inflammatory response. CF transmembrane conductance regulator (CFTR) modulators have shown to improve clinical...

Full description

Bibliographic Details
Main Authors: Dirk Westhölter, Jonas Raspe, Hendrik Uebner, Johannes Pipping, Mona Schmitz, Svenja Straßburg, Sivagurunathan Sutharsan, Matthias Welsner, Christian Taube, Sebastian Reuter
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
pulmonary infection
cytokines
immunophenotyping
CFTR modulator therapy
cystic fibrosis - immunology
Pseudomonas aeruginosa
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107437/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107437/full

Similar Items