Vaccine Protection of Mice With Primary Immunodeficiencies Against Disseminated Coccidioidomycosis

Vaccine Protection of Mice With Primary Immunodeficiencies Against Disseminated Coccidioidomycosis

Disseminated coccidioidomycosis (DCM), often a severe and refractory disease leading to poor outcomes, is a risk for people with certain primary immunodeficiencies (PID). Several DCM-associated PID (STAT4, STAT3, IFNγ, and Dectin-1) are modeled in mice. To determine if vaccination could provide thes...

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Bibliographic Details
Main Authors: Daniel A. Powell, Amy P. Hsu, Christine D. Butkiewicz, Hien T. Trinh, Jeffrey A. Frelinger, Steven M. Holland, John N. Galgiani, Lisa F. Shubitz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
coccidioidomycosis
vaccine
disseminated
immunodeficiency
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.790488/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.790488/full

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