Exploring the Anticancer Effects of Brominated Plastoquinone Analogs with Promising Cytotoxic Activity in MCF-7 Breast Cancer Cells via Cell Cycle Arrest and Oxidative Stress Induction

Exploring the Anticancer Effects of Brominated Plastoquinone Analogs with Promising Cytotoxic Activity in MCF-7 Breast Cancer Cells via Cell Cycle Arrest and Oxidative Stress Induction

Plastoquinone analogs are privileged structures among the known antiproliferative natural product-based compound families. Exploiting one of these analogs as a lead structure, we report the investigation of the brominated PQ analogs (BrPQ) in collaboration with the National Cancer Institute of Bethe...

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Bibliographic Details
Main Authors: Ayse Tarbin Jannuzzi, Ayse Mine Yilmaz Goler, Nilüfer Bayrak, Mahmut Yıldız, Hatice Yıldırım, Betul Karademir Yilmaz, Deepak Shilkar, Raghusrinivasan Jayaprakash Venkatesan, Venkatesan Jayaprakash, Amaç Fatih TuYuN
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceuticals
Subjects:
quinone
plastoquinones
antiproliferative activity
cytotoxicity
cell cycle
oxidative stress
Online Access:https://www.mdpi.com/1424-8247/15/7/777

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https://www.mdpi.com/1424-8247/15/7/777

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