Sciatic Nerve Intrafascicular Injection Induces Neuropathy by Activating the Matrix Modulators MMP-9 and TIMP-1

Sciatic Nerve Intrafascicular Injection Induces Neuropathy by Activating the Matrix Modulators MMP-9 and TIMP-1

Background: Peripheral nerve block (PNB) under echo guidance may not prevent intrafascicular anesthetic injection-induced nerve injury. This study investigated whether unintended needle piercing alone, or the intrafascicular nerve injectant could induce neuropathy.Methods: 120 adult male Sprague-Daw...

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Bibliographic Details
Main Authors: Kuang-Yi Tseng, Hung-Chen Wang, Kai-Feng Cheng, Yi-Hsuan Wang, Lin-Li Chang, Kuang-I Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
intrafascicular injection
neuropathic pain
TIMP-1
MMP-9
vascular permeability
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.859982/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.859982/full

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