Nifedipine Ameliorates Cellular Differentiation Defects of Smn-Deficient Motor Neurons and Enhances Neuromuscular Transmission in SMA Mice

Nifedipine Ameliorates Cellular Differentiation Defects of Smn-Deficient Motor Neurons and Enhances Neuromuscular Transmission in SMA Mice

In spinal muscular atrophy (SMA), mutations in or loss of the <i>Survival Motor Neuron 1</i> (<i>SMN1</i>) gene reduce full-length SMN protein levels, which leads to the degeneration of a percentage of motor neurons. In mouse models of SMA, the development and maintenance of...

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Bibliographic Details
Main Authors: Rocio Tejero, Mohammad Alsakkal, Luisa Hennlein, Ana M. Lopez-Cabello, Sibylle Jablonka, Lucia Tabares
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
spinal muscular atrophy
motor neurons
synaptic transmission
neuromuscular junction
calcium channels
nifedipine
Online Access:https://www.mdpi.com/1422-0067/24/8/7648

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https://www.mdpi.com/1422-0067/24/8/7648

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