The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury

The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury

Acute lung injury caused by inhalation of pathogens leads to mortality, but the mechanisms are unclear. Here, the authors show in mice that that loss of the mitochondrial calcium uniporter (MCU) of alveolar type 2 cells (AT2) impaired mitochondrial Ca2+ buffering and surfactant secretion, and increa...

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Bibliographic Details
Main Authors: Mohammad Naimul Islam, Galina A. Gusarova, Shonit R. Das, Li Li, Eiji Monma, Murari Anjaneyulu, Liberty Mthunzi, Sadiqa K. Quadri, Edward Owusu-Ansah, Sunita Bhattacharya, Jahar Bhattacharya
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33543-y

Internet

https://doi.org/10.1038/s41467-022-33543-y

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