The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury
Acute lung injury caused by inhalation of pathogens leads to mortality, but the mechanisms are unclear. Here, the authors show in mice that that loss of the mitochondrial calcium uniporter (MCU) of alveolar type 2 cells (AT2) impaired mitochondrial Ca2+ buffering and surfactant secretion, and increa...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33543-y |
| _version_ | 1828194635795660800 |
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| author | Mohammad Naimul Islam Galina A. Gusarova Shonit R. Das Li Li Eiji Monma Murari Anjaneyulu Liberty Mthunzi Sadiqa K. Quadri Edward Owusu-Ansah Sunita Bhattacharya Jahar Bhattacharya |
| author_facet | Mohammad Naimul Islam Galina A. Gusarova Shonit R. Das Li Li Eiji Monma Murari Anjaneyulu Liberty Mthunzi Sadiqa K. Quadri Edward Owusu-Ansah Sunita Bhattacharya Jahar Bhattacharya |
| author_sort | Mohammad Naimul Islam |
| collection | DOAJ |
| description | Acute lung injury caused by inhalation of pathogens leads to mortality, but the mechanisms are unclear. Here, the authors show in mice that that loss of the mitochondrial calcium uniporter (MCU) of alveolar type 2 cells (AT2) impaired mitochondrial Ca2+ buffering and surfactant secretion, and increased mortality, in response to LPS instillation, suggesting the MCU as a potential therapeutic target in ALI. |
| first_indexed | 2024-04-12T09:29:34Z |
| format | Article |
| id | doaj.art-a9cc5eeffd654bdc8a97a85b6dd2ed80 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T09:29:34Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a9cc5eeffd654bdc8a97a85b6dd2ed802022-12-22T03:38:24ZengNature PortfolioNature Communications2041-17232022-10-0113111510.1038/s41467-022-33543-yThe mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injuryMohammad Naimul Islam0Galina A. Gusarova1Shonit R. Das2Li Li3Eiji Monma4Murari Anjaneyulu5Liberty Mthunzi6Sadiqa K. Quadri7Edward Owusu-Ansah8Sunita Bhattacharya9Jahar Bhattacharya10Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia UniversityDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia UniversityDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia UniversityDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia UniversityDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia UniversityDepartment of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia UniversityDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia UniversityDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia UniversityDepartment of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia UniversityDepartment of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia UniversityDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia UniversityAcute lung injury caused by inhalation of pathogens leads to mortality, but the mechanisms are unclear. Here, the authors show in mice that that loss of the mitochondrial calcium uniporter (MCU) of alveolar type 2 cells (AT2) impaired mitochondrial Ca2+ buffering and surfactant secretion, and increased mortality, in response to LPS instillation, suggesting the MCU as a potential therapeutic target in ALI.https://doi.org/10.1038/s41467-022-33543-y |
| spellingShingle | Mohammad Naimul Islam Galina A. Gusarova Shonit R. Das Li Li Eiji Monma Murari Anjaneyulu Liberty Mthunzi Sadiqa K. Quadri Edward Owusu-Ansah Sunita Bhattacharya Jahar Bhattacharya The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury Nature Communications |
| title | The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury |
| title_full | The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury |
| title_fullStr | The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury |
| title_full_unstemmed | The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury |
| title_short | The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury |
| title_sort | mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury |
| url | https://doi.org/10.1038/s41467-022-33543-y |
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