Sigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca<sup>2+</sup> Leak during Early ER Stress

Sigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca<sup>2+</sup> Leak during Early ER Stress

The endoplasmic reticulum (ER) is a complex, multifunctional organelle of eukaryotic cells and responsible for the trafficking and processing of nearly 30% of all human proteins. Any disturbance to these processes can cause ER stress, which initiates an adaptive mechanism called unfolded protein res...

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Bibliographic Details
Main Authors: Zhanat Koshenov, Furkan E. Oflaz, Martin Hirtl, Johannes Pilic, Olaf A. Bachkoenig, Benjamin Gottschalk, Corina T. Madreiter-Sokolowski, Rene Rost, Roland Malli, Wolfgang F. Graier
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Metabolites
Subjects:
sigma-1 receptor
mitochondrial bioenergetics
ER stress
UPR
ER Ca<sup>2+</sup> leak
mitochondrial Ca<sup>2+</sup>
Online Access:https://www.mdpi.com/2218-1989/11/7/422

Internet

https://www.mdpi.com/2218-1989/11/7/422

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