Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction

Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction

Kinase-targeted agents demonstrate antitumor activity in advanced metastatic clear cell renal cell carcinoma (ccRCC), which remains largely incurable. Integration of genomic approaches through small-molecules and genetically based high-throughput screening holds the promise of improved discovery of...

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Bibliographic Details
Main Authors: Sofia Giacosa, Catherine Pillet, Irinka Séraudie, Laurent Guyon, Yann Wallez, Caroline Roelants, Christophe Battail, Bertrand Evrard, Frédéric Chalmel, Caroline Barette, Emmanuelle Soleilhac, Marie-Odile Fauvarque, Quentin Franquet, Clément Sarrazin, Nicolas Peilleron, Gaëlle Fiard, Jean-Alexandre Long, Jean-Luc Descotes, Claude Cochet, Odile Filhol
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
ccRCC
ATM
CK2
kinase inhibitor
HIF-2α
ROS pathway
Online Access:https://www.mdpi.com/2072-6694/13/3/576

Internet

https://www.mdpi.com/2072-6694/13/3/576

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