GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance

GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance

Genomic amplification of the androgen receptor (AR) is an established mechanism of antiandrogen resistance in prostate cancer. Here, we show that the magnitude of AR signaling output, independent of AR genomic alteration or expression level, also contributes to antiandrogen resistance, through upreg...

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Bibliographic Details
Main Authors: Eugine Lee, John Wongvipat, Danielle Choi, Ping Wang, Young Sun Lee, Deyou Zheng, Philip A Watson, Anuradha Gopalan, Charles L Sawyers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
intra-tumoral heterogeneity
AR signaling output
AR coactivator
enzalutamide
GREB1
Online Access:https://elifesciences.org/articles/41913

Internet

https://elifesciences.org/articles/41913

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