Circulating multimeric immune complexes contribute to immunopathology in COVID-19

Circulating multimeric immune complexes contribute to immunopathology in COVID-19

During viral infections high levels of antibodies can form soluble immune complexes (sICs) with antigen and trigger Fcγ receptors (FcγR) leading to increased immunopathology. Here the authors measure FcγRs activation by sICs and consider how these may lead to excessive immunopathology during severe...

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Bibliographic Details
Main Authors: Jakob Ankerhold, Sebastian Giese, Philipp Kolb, Andrea Maul-Pavicic, Reinhard E. Voll, Nathalie Göppert, Kevin Ciminski, Clemens Kreutz, Achim Lother, Ulrich Salzer, Wolfgang Bildl, Tim Welsink, Nils G. Morgenthaler, Andrea Busse Grawitz, Florian Emmerich, Daniel Steinmann, Daniela Huzly, Martin Schwemmle, Hartmut Hengel, Valeria Falcone
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32867-z

Internet

https://doi.org/10.1038/s41467-022-32867-z

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