Circulating multimeric immune complexes contribute to immunopathology in COVID-19
During viral infections high levels of antibodies can form soluble immune complexes (sICs) with antigen and trigger Fcγ receptors (FcγR) leading to increased immunopathology. Here the authors measure FcγRs activation by sICs and consider how these may lead to excessive immunopathology during severe...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32867-z |
| _version_ | 1811236326701268992 |
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| author | Jakob Ankerhold Sebastian Giese Philipp Kolb Andrea Maul-Pavicic Reinhard E. Voll Nathalie Göppert Kevin Ciminski Clemens Kreutz Achim Lother Ulrich Salzer Wolfgang Bildl Tim Welsink Nils G. Morgenthaler Andrea Busse Grawitz Florian Emmerich Daniel Steinmann Daniela Huzly Martin Schwemmle Hartmut Hengel Valeria Falcone |
| author_facet | Jakob Ankerhold Sebastian Giese Philipp Kolb Andrea Maul-Pavicic Reinhard E. Voll Nathalie Göppert Kevin Ciminski Clemens Kreutz Achim Lother Ulrich Salzer Wolfgang Bildl Tim Welsink Nils G. Morgenthaler Andrea Busse Grawitz Florian Emmerich Daniel Steinmann Daniela Huzly Martin Schwemmle Hartmut Hengel Valeria Falcone |
| author_sort | Jakob Ankerhold |
| collection | DOAJ |
| description | During viral infections high levels of antibodies can form soluble immune complexes (sICs) with antigen and trigger Fcγ receptors (FcγR) leading to increased immunopathology. Here the authors measure FcγRs activation by sICs and consider how these may lead to excessive immunopathology during severe SARS-CoV-2 infection. |
| first_indexed | 2024-04-12T12:08:23Z |
| format | Article |
| id | doaj.art-a9d748cc00644a7f80d5d264a6b23e8f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T12:08:23Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a9d748cc00644a7f80d5d264a6b23e8f2022-12-22T03:33:40ZengNature PortfolioNature Communications2041-17232022-09-0113111510.1038/s41467-022-32867-zCirculating multimeric immune complexes contribute to immunopathology in COVID-19Jakob Ankerhold0Sebastian Giese1Philipp Kolb2Andrea Maul-Pavicic3Reinhard E. Voll4Nathalie Göppert5Kevin Ciminski6Clemens Kreutz7Achim Lother8Ulrich Salzer9Wolfgang Bildl10Tim Welsink11Nils G. Morgenthaler12Andrea Busse Grawitz13Florian Emmerich14Daniel Steinmann15Daniela Huzly16Martin Schwemmle17Hartmut Hengel18Valeria Falcone19Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgDepartment of Rheumatology and Clinical Immunology, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgDepartment of Rheumatology and Clinical Immunology, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgInstitute of Medical Biometry and Statistics, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgDepartment of Cardiology and Angiology I, University Heart Center, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgDepartment of Rheumatology and Clinical Immunology, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgInstitute of Physiology II, Faculty of Medicine, Albert-Ludwigs-University of FreiburgInVivo BioTech Services GmbHInVivo BioTech Services GmbHInstitute of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Albert-Ludwigs-University of FreiburgInstitute for Transfusion Medicine and Gene Therapy, Freiburg University Medical Center, Faculty of Medicine, University of FreiburgOccupational Medical Service, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University of FreiburgDuring viral infections high levels of antibodies can form soluble immune complexes (sICs) with antigen and trigger Fcγ receptors (FcγR) leading to increased immunopathology. Here the authors measure FcγRs activation by sICs and consider how these may lead to excessive immunopathology during severe SARS-CoV-2 infection.https://doi.org/10.1038/s41467-022-32867-z |
| spellingShingle | Jakob Ankerhold Sebastian Giese Philipp Kolb Andrea Maul-Pavicic Reinhard E. Voll Nathalie Göppert Kevin Ciminski Clemens Kreutz Achim Lother Ulrich Salzer Wolfgang Bildl Tim Welsink Nils G. Morgenthaler Andrea Busse Grawitz Florian Emmerich Daniel Steinmann Daniela Huzly Martin Schwemmle Hartmut Hengel Valeria Falcone Circulating multimeric immune complexes contribute to immunopathology in COVID-19 Nature Communications |
| title | Circulating multimeric immune complexes contribute to immunopathology in COVID-19 |
| title_full | Circulating multimeric immune complexes contribute to immunopathology in COVID-19 |
| title_fullStr | Circulating multimeric immune complexes contribute to immunopathology in COVID-19 |
| title_full_unstemmed | Circulating multimeric immune complexes contribute to immunopathology in COVID-19 |
| title_short | Circulating multimeric immune complexes contribute to immunopathology in COVID-19 |
| title_sort | circulating multimeric immune complexes contribute to immunopathology in covid 19 |
| url | https://doi.org/10.1038/s41467-022-32867-z |
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