The Reversible Carnitine Palmitoyltransferase 1 Inhibitor (Teglicar) Ameliorates the Neurodegenerative Phenotype in a Drosophila Huntington’s Disease Model by Acting on the Expression of Carnitine-Related Genes

The Reversible Carnitine Palmitoyltransferase 1 Inhibitor (Teglicar) Ameliorates the Neurodegenerative Phenotype in a Drosophila Huntington’s Disease Model by Acting on the Expression of Carnitine-Related Genes

Huntington’s disease (HD) is a dramatic neurodegenerative disorder caused by the abnormal expansion of a CAG triplet in the huntingtin gene, producing an abnormal protein. As it leads to the death of neurons in the cerebral cortex, the patients primarily present with neurological symptoms, but recen...

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Bibliographic Details
Main Authors: Carla Bertapelle, Maria Rosaria Carillo, Nunzio Antonio Cacciola, Yulii V. Shidlovskii, Gianfranco Peluso, Filomena Anna Digilio
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
<i>Drosophila melanogaster</i>
Huntington’s disease
neurodegeneration
L-carnitine
carnitine shuttle
mitochondria
Online Access:https://www.mdpi.com/1420-3049/27/10/3125

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https://www.mdpi.com/1420-3049/27/10/3125

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