Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence.
BACKGROUND:Chronic infection with hepatitis B virus (HBV) arising in childhood is associated with hepatocellular carcinoma in adult life. Between 1986 and 1990, approximately 120,000 Gambian newborns were enrolled in a randomised controlled trial to assess the effectiveness of infant HBV vaccination...
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Public Library of Science (PLoS)
2007-08-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC1940311?pdf=render |
| _version_ | 1819045792918274048 |
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| author | Marianne A B van der Sande Pauline A Waight Maimuna Mendy Syed Zaman Steve Kaye Omar Sam Abi Kahn David Jeffries Aveika A Akum Andrew J Hall Ebrima Bah Samuel J McConkey Pierre Hainaut Hilton C Whittle |
| author_facet | Marianne A B van der Sande Pauline A Waight Maimuna Mendy Syed Zaman Steve Kaye Omar Sam Abi Kahn David Jeffries Aveika A Akum Andrew J Hall Ebrima Bah Samuel J McConkey Pierre Hainaut Hilton C Whittle |
| author_sort | Marianne A B van der Sande |
| collection | DOAJ |
| description | BACKGROUND:Chronic infection with hepatitis B virus (HBV) arising in childhood is associated with hepatocellular carcinoma in adult life. Between 1986 and 1990, approximately 120,000 Gambian newborns were enrolled in a randomised controlled trial to assess the effectiveness of infant HBV vaccination on the prevention of hepatocellular carcinoma in adulthood. These children are now in adolescence and approaching adulthood, when the onset of sexual activity may challenge their hepatitis B immunity. Thus a booster dose in adolescence could be important to maintain long-term protection. METHODS:Fifteen years after the start of the HBV infant vaccination study, 492 vaccinated and 424 unvaccinated children were identified to determine vaccine efficacy against infection and carriage in adolescence. At the same time, 297 of the 492 infant-vaccinated subjects were randomly offered a booster dose of HBV vaccine. Anti-HBs was measured before the booster, and two weeks and 1 year afterwards (ISRCTN71271385). RESULTS:Vaccine efficacy 15 years after vaccination was 67.0% against infection as manifest by anti-HBc positivity (95% CI 58.2-74.6%), and 96.6% against HBsAg carriage (95% CI 91.5-100%). 31.2% of participants had detectable anti-HBs with a GMC of 32 IU/l. For 168 boosted participants GMC anti-HBs responses were 38 IU/l prior to vaccination, 524 IU/l two weeks after boosting, and 101 IU/l after 1 year. CONCLUSIONS:HBV vaccination in infants confers very good protection against carriage up to 15 years of age, although a large proportion of vaccinated subjects did not have detectable anti-HBs at this age. The response to boosting persisted for at least a year. TRIAL REGISTRATION:Controlled-Trials.com ISRCTN71271385. |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T10:34:13Z |
| publishDate | 2007-08-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-a9de61d27a39496f97558ce8e701f1822022-12-21T19:07:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032007-08-0128e75310.1371/journal.pone.0000753Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence.Marianne A B van der SandePauline A WaightMaimuna MendySyed ZamanSteve KayeOmar SamAbi KahnDavid JeffriesAveika A AkumAndrew J HallEbrima BahSamuel J McConkeyPierre HainautHilton C WhittleBACKGROUND:Chronic infection with hepatitis B virus (HBV) arising in childhood is associated with hepatocellular carcinoma in adult life. Between 1986 and 1990, approximately 120,000 Gambian newborns were enrolled in a randomised controlled trial to assess the effectiveness of infant HBV vaccination on the prevention of hepatocellular carcinoma in adulthood. These children are now in adolescence and approaching adulthood, when the onset of sexual activity may challenge their hepatitis B immunity. Thus a booster dose in adolescence could be important to maintain long-term protection. METHODS:Fifteen years after the start of the HBV infant vaccination study, 492 vaccinated and 424 unvaccinated children were identified to determine vaccine efficacy against infection and carriage in adolescence. At the same time, 297 of the 492 infant-vaccinated subjects were randomly offered a booster dose of HBV vaccine. Anti-HBs was measured before the booster, and two weeks and 1 year afterwards (ISRCTN71271385). RESULTS:Vaccine efficacy 15 years after vaccination was 67.0% against infection as manifest by anti-HBc positivity (95% CI 58.2-74.6%), and 96.6% against HBsAg carriage (95% CI 91.5-100%). 31.2% of participants had detectable anti-HBs with a GMC of 32 IU/l. For 168 boosted participants GMC anti-HBs responses were 38 IU/l prior to vaccination, 524 IU/l two weeks after boosting, and 101 IU/l after 1 year. CONCLUSIONS:HBV vaccination in infants confers very good protection against carriage up to 15 years of age, although a large proportion of vaccinated subjects did not have detectable anti-HBs at this age. The response to boosting persisted for at least a year. TRIAL REGISTRATION:Controlled-Trials.com ISRCTN71271385.http://europepmc.org/articles/PMC1940311?pdf=render |
| spellingShingle | Marianne A B van der Sande Pauline A Waight Maimuna Mendy Syed Zaman Steve Kaye Omar Sam Abi Kahn David Jeffries Aveika A Akum Andrew J Hall Ebrima Bah Samuel J McConkey Pierre Hainaut Hilton C Whittle Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence. PLoS ONE |
| title | Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence. |
| title_full | Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence. |
| title_fullStr | Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence. |
| title_full_unstemmed | Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence. |
| title_short | Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence. |
| title_sort | long term protection against hbv chronic carriage of gambian adolescents vaccinated in infancy and immune response in hbv booster trial in adolescence |
| url | http://europepmc.org/articles/PMC1940311?pdf=render |
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