CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading

CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading

Centromeres are unique chromosomal loci that promote the assembly of kinetochores, macromolecular complexes that bind spindle microtubules during mitosis. In most organisms, centromeres lack defined genetic features. Rather, they are specified epigenetically by a centromere-specific histone H3 varia...

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Bibliographic Details
Main Authors: Dongqing Pan, Kerstin Klare, Arsen Petrovic, Annika Take, Kai Walstein, Priyanka Singh, Arnaud Rondelet, Alexander W Bird, Andrea Musacchio
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
kinetochore
centromere
cell cycle
CENP-A
chromatin
Online Access:https://elifesciences.org/articles/23352

Internet

https://elifesciences.org/articles/23352

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